Abstract: To make enhancement on high hardness, hydrophilicity and the wear resistance for denture base composite materials, polymethyl methacrylate (PMMA) and graphene oxide (GO) were mixed successfully by the step of liquid-phase ultrasonication dispersion, high-speed ball mill mixing, and finally the samples of denture base reinforced with GO were processed according to the processing method of dental conventional method. The microstructure, micro-hardness and the surface hydrophilic of the GO/PMMA composites were observed and evaluated by using a high-resolution scanning electron microscope, Vicker micro-hardness meter and the contact angle analysis apparatus. Under the lubrication of artificial saliva, the wear properties of the GO/PMMA composites were investigated using a reciprocating friction testing apparatus of UMT-3MT. The surface topographies and their wear scratches of these composites were observed by Micro-XAM three-dimensional surface profile. The results show that compared with the routine denture base material,the micro- hardness of GO/PMMA composites increased with the increasing GO content. However, the trend became weaker when the addition amount of GO was greater than 0.1%. The static contact angle decreased gradually with the addition amount of GO. When the addition amount of GO was lower than 0.1%, the coefficient of friction and wear rate of these composites were lower than the control group, while the addition was higher than 0.1%, the results were reversed. The wear resistance of GO/PMMA composites were enhanced by the addition of the enhance filler of GO. The denture base material reinforced with GO shows good properties for dental clinical application.